|
KMID : 0861020020170010039
|
|
Korea Journal of Herbology
2002 Volume.17 No. 1 p.39 ~ p.54
|
|
|
Study on the Effects of Xanthii Fructus about the anti - allergic Action on IC - 2 Cells
|
|
徐榮培/Seo, Young-Bae
崔永奉/李龍求/李永喆/Choi, Young-Bong/Lee, Yong-Koo/Lee, Young-Cheol
|
|
|
Abstract
|
|
|
This study was carried out for the purpose of knowing the effect from anti-allergic action of B cells and the IC-2 mast cells the extraction from Xanthii Fructus(EXF). In order to know the effect of the cytotoxicity from extraction of Xanthii Fructus, we had to examine the safe density of EXF on lung fibroblast cells of the mouse (mLPCs). We also attempted to resolve the relationship cytotoxicity. The effect was on the organization of cytokine gene expression from the increas and divorce of the B cells and allergic acting by EXF, we found it necessary to examine the IC-2 cells and B cells. We examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of EXF on the increase and divorce of the B cells by ^3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and nitric oxide (NO).
The results are as follows :
1. EXF did not show cytotoxicity against mLFCs.
2. According to the inspection on the effect on IC-2 cells gene expression by EXF, we found out the following results:
EXF reduced IL-4, IL-6, GM-CSF, TNF-α gene expression and histamine release of IC-2 cells. The EXF inhibited signs of inflammation IC-2 cells.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|